There will be blood: Crime rates in shale-rich U.S. counties

There Will Be Blood: Crime Rates in Shale-Rich U.S. Counties

“There will be blood” from fibroblasts

The blood system is continuously replenished from a rare population of hematopoietic stem cells (HSCs) that balance self-renewal and differentiation. It is believed that HSCs emerge during embryogenesis from a population of hemogenic endothelial cells at sites like the aorta-gonad-mesonephros (AGM) region and placenta. Transplantation of HSCs is a widely utilized cell therapy for a range of gen...

There will be blood: targeting tumor vasculature.

Wherever there is cancer, there will be blood and blood vessels to support tumor growth. While the majority of anticancer drugs are designed to directly kill tumor cells, recent strategies are focusing on drugs that indirectly kill cancer cells by targeting the tumor microenvironment and tumor vasculature. This strategy gained a significant boost with the approval of the angiogenesis inhibitor ...

Will He Be There?

This paper focuses on an unsettling example of experimental labour - the Human Landing Catch (HLC). The HLC is a cheap and reliable technique to produce data on mosquito densities in a defined area. It requires only a human volunteer to sit over night with his legs exposed, a headlamp to spot mosquitoes, and a rubber tube and plastic cup to catch them as they come to feed on him. The HLC formed...

What got us here will not get us there.

This is an exciting yet trying time for people living with neuromuscular diseases and those who care for them. The exciting aspect is that at last the advances in genetics and translational research have resulted in clinical trials testing novel compounds. Examples include the exon-skipping approaches in Duchenne Muscular Dystrophy (DMD). Resulting from a sophisticated understanding of the cons...